Efficient Gas-Liquid Contact in Continuous Flow Synthesis: Palladium-Catalyzed Carbonylations using Teflon AF-2400.

Added on:
1 Jan, 2025

We report the continuous flow, palladiumcatalyzed carbomethylation of aryl-, heteroaromatic- and vinyl- iodides using a novel Tube-in-Tube gas-liquid reactor. The flow process afforded methyl ester products in short reaction times, employing moderate CO pressure. The use of inline scavenging affected removal of the palladium catalyst, generating pure products. Also presented is a preliminary investigation into the quantification of CO dissolution at different pressure and flow rates by real-time, in-line FTIR analysis and gas burette measurements. We further demonstrate the degassing of a CO gas/liquid stream via a second reactor operating under reduced pressure, permitting multi-step, downstream flow processing.

  • Koos, P
  • Polyzos, A
  • O'Brien, M
  • Baxendale, IR
  • Ley, SV
  • Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
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