Direct Oxime Etherification of Inert C (Sp3)-H Via Photo-Driven Hat in Batch or Continuous Flow Mode

An efficient photocatalytic strategy for the direct oxime etherification of unactivated C(sp³)-H bonds has been developed through hydrogen atom transfer (HAT) activation, employing low-loadings of FeCl₃ as the catalyst under blue light irradiation. A broad substrate scope has been demonstrated, with excellent functional group tolerance observed, including cycloalkanes, ethers, amides, sulfonamides, phosphoramides, and ketones. Furthermore, the reaction system has been shown to exhibit remarkable scalability when applied in a continuous-flow photoreactor, enabling practical gram-scale production of pharmaceutically relevant oxime ether derivatives with improved yields.

• Pan, Y
• Qiao, K
• Shao, B
• Du, X
• Jiang, W
• Shi,

• Dalian University of Technology

• Request a Brochure
• Request more Info
• Request a Quote