Development of a Safe and Efficient Continuous Flow Method for the Synthesis of 3‐Difluoromethoxypyridine Derivatives

A safe, efficient, and scalable continuous-flow-chemistry protocol for the O-difluoromethylation of two 3-hydroxypyridine building blocks has been developed. It is highlighted that continuous flow chemistry has been firmly established within Novartis Biomedical Research, and, when appropriately implemented, is capable of enabling the continuous supply of material from the initial identification of a potentially valuable intermediate in a discovery project through to its clinical evaluation.

• Lehmann, H
• Ruppen, T
• Oswald, S
• Ye, N
• Tian, X
• Gu, X
• Dai, C
• Fairhurst, R

• Novartis Pharma AG, Biomedical Research, Novartis Campus, WSJ-088, 4056 Basel, SWITZERLAND

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