Continuous Flow for the Photochemical Synthesis of 3-Substituted Quinolines

A new continuous-flow strategy was developed for the safe synthesis of 3-cyanoquinolines from 2-(azidomethyl)-3-(aryl)prop-2-enenitriles within minutes. The versatility of the method was demonstrated by using a set of aromatic aldehydes as starting materials, leading to previously unexplored quinolines with satisfactory yields. The limited synthetic accessibility of 3-cyanoquinolines, which are valuable building blocks in medicinal chemistry, has constrained their use.

• Molnár, M
• Fődi, T
• Tatai, J
• Kun, V
• Balázs, B
• Gáti, T
• Dargó, G
• Nyerges, M

• Servier Research Institute of Medicinal Chemistry, 7, Záhony Street, 1031 Budapest, Hungary

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