Continuous Flow Block Copolymer Nanoaggregate Synthesis and Their Flow Dialysis Purification

The self-assembly of block copolymers into nanoparticles of defined size and morphology is facilitated through the use of continuous flow synthesis methods. Using flow processes, nanoparticles are obtained at higher rates, with improved consistency, under greener conditions, and with significantly reduced batch-to-batch variability when compared to traditional batch methods. The methodology for formulating block copolymers in a flow setup is described, and corresponding design strategies are explained. Furthermore, the purification of the resulting particles is carried out via flow dialysis, representing a second critical step in the synthesis process, which, when performed in batch, is typically time- and resource-intensive. Through these described methods, a pathway is opened toward reproducible block copolymer nanoparticle synthesis, as well as the development of automated and high-throughput material screening systems.

• Ammini, G
• Weerarathna, L
• Junkers, T

• Polymer Reaction Design Group School of Chemistry Monash University 19 Rainforest Walk, Building 23 Clayton 3800 VIC Australia

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