Application Note 67: Generation of Grignard reagents on demand


    This application note illustrates the capabilities of Vapourtec’s new packed bed reactor for a fast, consistent generation of Grignard reagents in flow. Under continuous flow conditions, an organic bromide reacts with magnesium packed inside the Variable Bed Flow Reactor, adjusting its volume to keep a constant packing density. In a second inline reactor, an aldehyde is added to the Grignard reagent to form a secondary alcohol.

    Join the Vapourtec Knowledge Base to access this Application note

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us