Application Note 67: Generation of Grignard reagents on demand

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    This application note illustrates the capabilities of Vapourtec’s new packed bed reactor for a fast, consistent generation of Grignard reagents in flow. Under continuous flow conditions, an organic bromide reacts with magnesium packed inside the Variable Bed Flow Reactor, adjusting its volume to keep a constant packing density. In a second inline reactor, an aldehyde is added to the Grignard reagent to form a secondary alcohol.

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