Application Note 51 – Palladium on Charcoal Slurries in Continuous Flow Hydrogenation

Using a Vapourtec E-Series with V-3 peristaltic pumps it has been possible to handle solids in flow, to perform a continuous flow hydrogenation of 4-(2-fluoro-4-nitrophenyl)morpholine to the Linezolid intermediate 3-fluoro-4-(4-morpholinyl)aniline, using ammonium formate, and a heterogeneous palladium on charcoal slurry.