Advanced Functional Macromolecular Architecture

Control over polymer architecture is a crucial parameter to manipulate macromolecular function, both in solution and on surface. Nature exemplifies this in enzymes, which show unmatched catalytic function due to their defined three-dimensional structure. In this thesis, peptide based single chain nanoparticles carrying the DHS sequence are utilized for the catalysis of ester hydrolysis reactions where the reaction rate may be increased. The catalytic triad is further investigated and combined with a novel peptide stapling chemistry based on pyridinedithiazolines. Finally, polymer brushes are obtained and photochemically manipulated to create complex patterns on surface at the nanoscopic level.

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