Advancing continuous flow techniques in effective trimethoprim oxidation: combatting bacterial resistance in wastewater

This work describes an innovative catalytic process for aqueous trimethoprim degradation, using a fixed-bed continuous flow reactor packed with a manganese(III) meso-substituted porphyrin covalently immobilized functionalized aminopropyl silica gel as the catalyst and H2O2 as a green oxidant. It exhibits remarkable activity and stability, maintaining its performance over extended periods (up to 8 hours) and achieving significant reductions in total organic carbon (TOC = 80%). Importantly, microbiological assays confirmed that this degradation process effectively converts trimethoprim into non-resistance-inducing products.

• Marques, DL
• Piccirillo, G
• Rodrigues, FMS
• Aroso, RT
• Dias, LD
• da Silva, GJ
• Calvete, MJF
• Pereira, MM

• CQC-IMS, Department of Chemistry, University of Coimbra, Rua Larga, 3004-535, Coimbra, Portugal

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