Electrochemical Trifluoromethylalkoxylation of Endocyclic Enamides in Batch and Flow

A regioselective electrochemical oxytrifluoromethylation of endocyclic enamides is reported. The 1,2‐difunctionalization proceeds under mild conditions and employs the inexpensive bench stable Langlois’ reagent. This multicomponent strategy gives access to a wide range of α,β‐substituted amines by means of various alcohols as nucleophiles in high yields and with good functional group tolerance. In addition, an electrochemically induced C−H trifluoromethylation of enamides has been developed. A continuous flow protocol using a commercial microflow electrochemical reactor was also developed with improved reaction performance and efficiency over traditional batch versions without any supporting electrolyte.

• Leclercq, E
• Barakat, W
• Maazaoui, R
• Penhoat, M
• Gillaizeau, I
• Chausset‐Boissarie, L

• Lille Univ. CNRS, MSAP, USR 3290 59000 Lille France

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