Visible Light Mediated N-Desulfonylation of N-Heterocycles using a Heteroleptic Copper (I) Complex as a Photocatalyst
- Cameron J. Hunter
- Michael J. Boyd
- Gregory D. May
- Robert Fimognari*
- Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United StatesRead the publication that featured this abstract
A photoredox protocol that uses a heteroleptic Cu (I) complex [Cu(dq)(BINAP)]BF4 has been developed for the photodeprotection of benzenesulfonyl protected N-heterocycles. A range of substrates were examined, including indazoles, indoles, pyrazoles, and benzimidazole, featuring both electron-rich and electron-deficient substituents, giving good yields of the N-heterocycle products with broad functional group tolerance. This transformation was also found to be amenable to flow reaction conditions.
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.