Two-Step Continuous-Flow Synthesis of 6-Membered Cyclic Iodonium Salts via Anodic Oxidation
- Julian Spils1
- Thomas Wirth2
- Boris J. Nachtsheim1
- 1Institute for Organic and Analytical Chemistry, University of Bremen, Leobener Straße 7, 28359 Bremen 2School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT (UK)Read the publication that featured this abstract
A multi-step continuous-flow procedure for the generation of six-membered diaryliodonium salts was developed. This is a significant improvement of existing batch methods with regard to scalability and atom economy. The method uses easily accessible benzyl acetates in Friedel-Crafts-like alkylations while a subsequent anodic oxidative cyclization directly generates the corresponding cyclic iodonium salts.
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