Transaminase‐catalyzed continuous synthesis of biogenic aldehydes

    • Martina L. Contente a
    • Francesca Paradisi *a,b
    • a School of Chemistry, University of Nottingham, University Park, Nottingham, NG7, 2RD, United Kingdom
    • b Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern

    The physiological role of biogenic aldehydes such as Dopal and Dopegal has been associated with cardiovascular and neurodegenerative disorders. The availability of these substrates is limited and robust synthetic methodologies would greatly facilitate further biological studies. Here we report on transaminase mediated single‐step process in continuous mode which leads to excellent product yields (90‐95%). Co‐immoblization of the PLP cofactor eliminated the need of exogenous addition of this reagent without affecting the longevity of the system, delivering a truly self‐sufficient process.

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