Taming photocatalysis in flow: easy and speedy preparation of α-aminoamide derivatives

• Ricardo I. Rodríguez^a
• Marina Sicignano^a
• Montaña J. García^a
• Rodrigo G. Enríquez^a
• Silvia Cabrera^b,c
• José Alemán^a,c,d

• ^aOrganic Chemistry Department, Science Faculty, Universidad Autónoma de Madrid, Madrid-28049, Spain
• ^bInorganic Chemistry Department, Science Faculty, Universidad Autónoma de Madrid, Madrid-28049, Spain
• ^cInstitute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain
• ^dCenter for Innovation in Advanced Chemistry (ORFEO-CINQA), Universidad Autónoma de Madrid, Spain

α-Aminoamides are reiterative molecular subunits in transcendental molecules, which bear attractive functionalities for (bio)synthetic purposes. Herein, their preparation by harnessing flow photocatalysis is described, which provides significant improvements over other catalytic methods in terms of efficiency while outperforming an analogous batch setup. A reaction time of five minutes, operational simplicity and absence of purification steps for the isolation of final products evidence an enhanced performance.

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