Synthesis of 2,4,6-Trisubstituted Pyrimidines via Iron-Catalyzed Homocoupling of α,β-Unsaturated Ketoximes

    • Kai Guoa
    • Gaochen Xua
    • Xuemei Wanga
    • Chenglong Jiaa
    • Huan Yana
    • Sai Zhanga
    • Qinghuan Wua
    • Ning Zhua
    • Zheng Fanga
    • Jindian Duana
    • aCollege of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University,30 Puzhu Rd S., Nanjing 211816, China

    A FeCl2-catalyzed homocoupling of α,β-unsaturated ketoximes in batch and flow is reported. This protocol demonstrates broad substrate scope and functional group tolerance, providing an alternate route toward the synthesis of 2,4,6-trisubstituted pyrimidines under mild conditions. Also a gram-scale reaction has been performed to evaluate the applicability of this method.

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