Synthesis of 2,4,6-Trisubstituted Pyrimidines via Iron-Catalyzed Homocoupling of α,β-Unsaturated Ketoximes
- Kai Guoa
- Gaochen Xua
- Xuemei Wanga
- Chenglong Jiaa
- Huan Yana
- Sai Zhanga
- Qinghuan Wua
- Ning Zhua
- Zheng Fanga
- Jindian Duana
- aCollege of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University,30 Puzhu Rd S., Nanjing 211816, ChinaRead the publication that featured this abstract
A FeCl2-catalyzed homocoupling of α,β-unsaturated ketoximes in batch and flow is reported. This protocol demonstrates broad substrate scope and functional group tolerance, providing an alternate route toward the synthesis of 2,4,6-trisubstituted pyrimidines under mild conditions. Also a gram-scale reaction has been performed to evaluate the applicability of this method.
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