Stereospecific Amination of Mesylated Cyclobutanol in Continuous Flow
- Matthieu Tissot
- Jérôme Jacq
- Patrick Pasau
- UCB Biopharma SPRL, Avenue de l’industrie, 1420 Braine l’Alleud, BelgiumRead the publication that featured this abstract
We report an amination of mesylated cyclobutanol enabled by a multistep continuous flow process. The flow sequence involved an azidation followed by a Staudinger reduction which avoids the handling and isolation of a hazardous alkyl azide compound. The process is stereospecific with the azidation step proceeding to complete stereochemical inversion.
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