Singlet oxygen oxidations in homogeneous continuous flow using a gas–liquid membrane reactor
Antonia Kouridaki, Kevin Huvaere
- EcoSynth NV, Industrielaan 12, 9800 Deinze, BelgiumRead the publication that featured this abstract
A flow chemistry reactor system for scalable photooxygenation reactions was developed using a gas–liquid reactor as key feature. Herein oxygen gas is dissolved under pressure in the reaction mixture to give a homogeneous flow regime prior to irradiation. The system enables safe mass transport of oxygen in an accurate manner simply by adjusting liquid flow rate, membrane temperature, and gas pressure as concluded after characterization of reactor behaviour. Quantification of oxygen supply as function of liquid flow rate and membrane temperature showed that 50 mM and 58 mM of oxygen were supplied to methanol and acetonitrile at 1 mL min−1 flow rate and 110 °C membrane temperature. With 100 mM measured at 90 °C, dichloromethane was most effective for oxygen uptake. Photooxidation of a model system, the furan derivative ethyl 3-(2-furyl)propanoate, was elaborated to validate the system for singlet oxygen chemistry, with reactor parameters being further optimized for maximum conversion. Scope of the system was demonstrated by performing a set of representative photochemical oxidations, including reaction with citronellol as first step in the synthesis of rose oxide.
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible :
- Precise :
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust :
- Easy to use :
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.