Selective Photochemical Continuous Flow Benzylic Monochlorination
- Robbie Radjagobaloua
- Miguel Imbrattab
- Julie Bergraserb
- Marion Gaudeaub
- Gildas Lyvinecb
- Dominique Delbrayelleb
- Olivier Jentzerb
- Jérémy Roudina
- Benjamin Larochea
- Stéphanie Ogniera
- Michael Tatouliana
- Janine Cossya
- Pierre-Georges Echeverriab
- aParis FLOW Tech − PSL, ENSCP, 11 rue Pierre et Marie Curie, Paris 75005, France
- bMinakem Recherche, 145 Chemin des Lilas, Beuvry-La-Forêt 59310, France
Read the publication that featured this abstractA selective photochemical monochlorination of 2-fluorotoluene has been developed by a continuous flow process using two different flow reactors, one for the tuning of the conditions and the second one for the scale-up. The key reaction parameters were optimized using one-factor-at-a-time and design of experiment methods, with the goal of minimizing the formation of the dichlorinated by-product. This transformation has been performed on a multi decagram scale.
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