Scale-Up and Optimization of a Continuous Flow Carboxylation of N-Boc-4,4-difluoropiperidine Using s-BuLi in THF

    • Jean-Paul Kestemonta
    • James R. Frostb
    • Jérôme Jacqa
    • Patrick Pasaua
    • Frédéric Perla
    • Julien Brownb
    • Matthieu Tissot*a
    • aUCB Biopharma SPRL, Avenue de l’industrie, 1420 Braine l’Alleud, Belgium
    • bUCB, 216 Bath Road, Slough SL1 3WE, United Kingdom

    We report a large-scale carboxylation of N-Boc-4,4-difluoropiperidine (1) enabled by a continuous flow process. The flow process involved N-Boc-directed α-deprotonation using s-BuLi in THF and subsequent trapping with CO2 gas. Flow chemistry enabled the safe and scalable preparation of 400 g of carboxylic acid 2 over the course of a day to support our medicinal chemistry research program.

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