Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles
- L. Hucka,b
- M. Bertona
- A. de la Hozb
- A. Díaz-Ortizb
- J. Alcázar*a
- * Corresponding author
- a Janssen Research and Development, Janssen-Cilag, S.A., C/ Jarama 75, Toledo, Spain
- b Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Ciudad Real, SpainRead the publication that featured this abstract
The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.
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