Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles
- L. Hucka,b
- M. Bertona
- A. de la Hozb
- A. Díaz-Ortizb
- J. Alcázar*a
- * Corresponding author
- a Janssen Research and Development, Janssen-Cilag, S.A., C/ Jarama 75, Toledo, Spain
- b Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Ciudad Real, SpainRead the publication that featured this abstract
The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible :
- Precise :
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust :
- Easy to use :
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.