The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions
- Steffen Glöckner
- Duc N. Tran
- Richard J. Ingham
- Sabine Fenner
- Zoe E. Wilson
- Claudio Battilocchio
- Steven V. Ley*
- Department of Chemistry, University of Cambridge, Cambridge, UKRead the publication that featured this abstract
A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.
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