The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

    • Steffen Glöckner
    • Duc N. Tran
    • Richard J. Ingham
    • Sabine Fenner
    • Zoe E. Wilson
    • Claudio Battilocchio
    • Steven V. Ley*
    • Department of Chemistry, University of Cambridge, Cambridge, UK

    A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.

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