The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.

• Steffen Glöckner
• Duc N. Tran
• Richard J. Ingham
• Sabine Fenner
• Zoe E. Wilson
• Claudio Battilocchio
• Steven V. Ley^*

• Department of Chemistry, University of Cambridge, Cambridge, UK

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