The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

• Anastasios Polyzos
• Matthew O’Brien
• Trine P. Petersen
• Ian R. Baxendale
• Steven V. Ley

• Innovative Technology Centre, Department of Chemistry, University of Cambridge

Keep it simple: A gas–liquid flow reactor has been developed based on a gas permeable tube-in-tube configuration which effectively delivers gas to a liquid substrate stream in a safe, continuous fashion. A series of carboxylic acids were prepared from the reaction of CO₂ with a range of Grignard reagents (see picture).

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