The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Added on:
8 Dec, 2011

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.

  • Kimberley A. Roper1
  • Heiko Lange1
  • Anastasios Polyzos1
  • Malcolm B. Berry2
  • Ian R. Baxendale1
  • Steven V. Ley1
  • 1Innovative Technology Centre, University of Cambridge
  • 2GlaxoSmithKline, Stevenage, UK
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