The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
- Kimberley A. Roper1
- Heiko Lange1
- Anastasios Polyzos1
- Malcolm B. Berry2
- Ian R. Baxendale1
- Steven V. Ley1
- 1Innovative Technology Centre, University of Cambridge
- 2GlaxoSmithKline, Stevenage, UK
Read the publication that featured this abstractHerein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.
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