The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

• Kimberley A. Roper¹
• Heiko Lange¹
• Anastasios Polyzos¹
• Malcolm B. Berry²
• Ian R. Baxendale¹
• Steven V. Ley¹

• ¹Innovative Technology Centre, University of Cambridge
• ²GlaxoSmithKline, Stevenage, UK

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.

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