The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

    • Kimberley A. Roper1
    • Heiko Lange1
    • Anastasios Polyzos1
    • Malcolm B. Berry2
    • Ian R. Baxendale1
    • Steven V. Ley1
    • 1Innovative Technology Centre, University of Cambridge
    • 2GlaxoSmithKline, Stevenage, UK

    Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.

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