ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit (HPLC) connections and can be used in combination with both meso- and microscale flow chemistry equipment. The iC IR analysis software (version 4.0) enables the monitoring of reagent consumption and product formation, aiding the rapid optimisation of procedures. Short-lived reactive intermediates can also be observed in situ, giving further mechanistic insight into complex transformations.

• Catherine F. Carter¹
• Heiko Lange¹
• Steven V. Ley¹
• Ian R. Baxendale¹
• Brian Wittkamp²
• Jon G. Goode³
• Nigel L. Gaunt³

• ¹Innovative Technology Centre, Department of Chemistry, University of Cambridge
• ²Mettler-Toledo AutoChem, USA
• ³Mettler-Toledo AutoChem, UK

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