Rapid Access to α-Alkoxy and α-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters
- Hannah E. Bartrum1
- David C. Blakemore2
- Christopher J. Moody1
- Christopher J. Hayes1
- 1School of Chemistry, University of Nottingham, UK
- 2Pfizer Global Research and Development, Sandwich, UKRead the publication that featured this abstract
Microreactors: A highly efficient continuous-flow process has been developed for the synthesis of diazoesters from arylsulfonylhydrazones by means of in-flow Bamford–Stevens reactions. Furthermore, a range of α-alkoxy and α-amino acid derivatives have been prepared in excellent yields through rhodium(II)-mediated O[BOND]H and N[BOND]H insertions, without the need to isolate or handle the potentially hazardous diazo species (see scheme).
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