Lead Diversification 2: Application to P38, gMTP and lead compounds

    • M. Abid Masood1
    • Marc Bazin2
    • Mark E. Bunnage1
    • Andrew Calabrese3
    • Mark Cox1
    • Sally-Ann Fancy1
    • Elizabeth Farrant1
    • David W. Pearce1
    • Manuel Perez1
    • Laure Hitzel1
    • Torren Peakman1
    • 1Worldwide Medicinal Chemistry, Pfizer, UK
    • 2Hepatochem, Cambridge, MA, USA
    • 3Celgene San Diego, USA

    Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.

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