Lead Diversification 2: Application to P38, gMTP and lead compounds

Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.

• M. Abid Masood¹
• Marc Bazin²
• Mark E. Bunnage¹
• Andrew Calabrese³
• Mark Cox¹
• Sally-Ann Fancy¹
• Elizabeth Farrant¹
• David W. Pearce¹
• Manuel Perez¹
• Laure Hitzel¹
• Torren Peakman¹

• ¹Worldwide Medicinal Chemistry, Pfizer, UK
• ²Hepatochem, Cambridge, MA, USA
• ³Celgene San Diego, USA

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