Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System

    • Charlotte M. Griffiths-Jones
    • Mark D. Hopkin
    • Daniel Jönsson
    • Steven V. Ley
    • David J. Tapolczay
    • Emma Vickerstaffe
    • Mark Ladlow
    • GlaxoSmithKline Cambridge Technology Centre, Cambridge

    A fully automated flow-through process for the production of secondary sulfonamides is presented. Primary sulfonamides were monoalkylated using a two-step “catch and release” protocol to generate library products of high purity. The automated flow synthesis platform incorporates four independent reactor columns and is able to perform automated column regeneration. A 48-member sulfonamide library was prepared as two 24-member sublibraries, affording library compounds in good yields and high purities without the need for further column chromatographic purification.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us