Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System
- Charlotte M. Griffiths-Jones
- Mark D. Hopkin
- Daniel Jönsson
- Steven V. Ley
- David J. Tapolczay
- Emma Vickerstaffe
- Mark Ladlow
- GlaxoSmithKline Cambridge Technology Centre, CambridgeRead the publication that featured this abstract
A fully automated flow-through process for the production of secondary sulfonamides is presented. Primary sulfonamides were monoalkylated using a two-step “catch and release” protocol to generate library products of high purity. The automated flow synthesis platform incorporates four independent reactor columns and is able to perform automated column regeneration. A 48-member sulfonamide library was prepared as two 24-member sublibraries, affording library compounds in good yields and high purities without the need for further column chromatographic purification.
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