Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906

    • Tomas Gustafsson
    • Henrik Sörensen
    • Fritiof Pontén*
    • Medicinal Chemistry, AstraZeneca R&D Mölndal, Sweden

    Early scale-up work of a promising reflux inhibitor AZD6906 is described. Two steps of an earlier route were adapted to be performed in continuous flow to avoid issues related to batch procedures, resulting in a robust method with reduced cost of goods and improved product quality. Toxic and reactive reagents and starting materials could be handled in a flow regime, thereby allowing safer and more convenient reaction optimization and production.

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