Decarboxylative biaryl synthesis in a continuous flow reactor

• ¹Paul P. Lange
• ¹Lukas J. Gooßen
• ²Philip Podmore
• ²Toby Underwood
• ²Nunzio Sciammetta

• ¹Technische Universität Kaiserslautern, Germany
• ²Pfizer Global R&D, Sandwich, UK

A practical protocol was developed that allows performing decarboxylative cross-coupling reactions in continuous flow reactors. Various biaryls were thus synthesized from aromatic carboxylic acids and aryl triflates using a Cu/Pd-catalyst system.

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