Decarboxylative biaryl synthesis in a continuous flow reactor

    • 1Paul P. Lange
    • 1Lukas J. Gooßen
    • 2Philip Podmore
    • 2Toby Underwood
    • 2Nunzio Sciammetta
    • 1Technische Universität Kaiserslautern, Germany
    • 2Pfizer Global R&D, Sandwich, UK

    A practical protocol was developed that allows performing decarboxylative cross-coupling reactions in continuous flow reactors. Various biaryls were thus synthesized from aromatic carboxylic acids and aryl triflates using a Cu/Pd-catalyst system.

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