C(sp³)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing
- Martin Brzozowski
- Jose A. Forni
- G. Paul Savage and Anastasios Polyzos*
- CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, AustraliaRead the publication that featured this abstract
An efficient nitro-Mannich type direct α-C(sp³)–H functionalisation of N-aryl-1,2,3,4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O2 as the terminal oxidant is described. The use of a Teflon AF-2400 membrane Tube-in-Tube reactor under continuous flow conditions allowed for considerable process intensification to be achieved relative to previous batch methods.
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