Continuous synthesis of pyridocarbazoles and initial photophysical and bioprobe characterization
- D. Tyler McQuade*ab
- Alexander G. O'Briena
- Markus Dörrc
- Rajathees Rajaratnamc
- Ursula Eisoldd
- Bopanna Monnandaa
- Tomoya Nobutaa
- Hans-Gerd Löhmannsröbend
- Eric Meggersc
- Peter H. Seebergerae
- a Department for Biomolecular Systems, Max Planck Institute for Colloids and Interfaces
- b Department of bChemistry and Biochemistry, Florida State University
- c Fachbereich Chemie, Philipps-Universität Marburg
- d Potsdam Institut für Chemie
- e Freie Universität Berlin
Read the publication that featured this abstractPyridocarbazoles when ligated to transition metals yield high affinity kinase inhibitors. While batch photocyclizations enable the synthesis of these heterocycles, the non-oxidative Mallory reaction only provides modest yields and difficult to purify mixtures. We demonstrate here that a flow-based Mallory cyclization provides superior results and enables observation of a clear isobestic point. The flow method allowed us to rapidly synthesize ten pyridocarbazoles and for the first time to document their interesting photophysical attributes. Preliminary characterization reveals that these molecules might be a new class of fluorescent bioprobe.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
Resource Centre
R-Series

The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series

The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.