Continuous Synthesis of Artemisinin-Derived Medicines

    • Kerry Gilmorea
    • Daniel Kopetzkia
    • Ju Weon Leeb
    • Zoltan Horvathb
    • D. Tyler McQuadea
    • Andreas Seidel-Morgensternb,c
    • Peter H. Seebergera,d
    • aMax-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Germany
    • bMax-Planck-Institute for Dynamics of Complex Technical Systems, Germany
    • cOtto-von-Guericke-University, Chair for Chemical Process Technology, Germany
    • dFreie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany

    Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

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