Continuous Synthesis of Artemisinin-Derived Medicines

• Kerry Gilmore^a
• Daniel Kopetzki^a
• Ju Weon Lee^b
• Zoltan Horvath^b
• D. Tyler McQuade^a
• Andreas Seidel-Morgenstern^b,c
• Peter H. Seeberger^a,d

• ^aMax-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Germany
• ^bMax-Planck-Institute for Dynamics of Complex Technical Systems, Germany
• ^cOtto-von-Guericke-University, Chair for Chemical Process Technology, Germany
• ^dFreie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany

Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

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