Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

    • Suzanne M. Opalka1
    • Jin Kyoon Park3
    • Ashley R. Longstreet2
    • D. Tyler McQuade2
    • 1Department of Chemistry and Biochemistry, Florida State University, USA
    • 2Department of Chemistry and Chemical Biology, Cornell University, USA
    • 3Department of Chemistry and Chemical Institute for Functional Materials, Pusan National University, Korea

    It is demonstrated that homogeneous N-heterocyclic carbene–copper(I)-chloride complexes can be prepared continuously by flowing NHC precursors through a packed bed of solid Cu2O suspended in molecular sieves. The method enables the synthesis of a wide range of complexes including those that are challenging to prepare using standard approaches. Our strategy enables both sustained output of complex production for long-term catalytic reactions (greater than 5 h) and for generation of gram quantities for storage (greater than 1 g of complex in ∼16 min).

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us

    Request a quote