Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography
- Alexander G. O’Brien1
- Zoltán Horváth3
- François Lévesque1
- Ju Weon Lee3
- Andreas Seidel-Morgenstern3
- Peter H. Seeberger1,2
- 1Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany
- 2Freie Universität Berlin, Germany
- 3Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, GermanyRead the publication that featured this abstract
Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module (see scheme).
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