Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography

• Alexander G. O’Brien¹
• Zoltán Horváth³
• François Lévesque¹
• Ju Weon Lee³
• Andreas Seidel-Morgenstern³
• Peter H. Seeberger^1,2

• ¹Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany
• ²Freie Universität Berlin, Germany
• ³Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module (see scheme).

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