Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography

    • Alexander G. O’Brien1
    • Zoltán Horváth3
    • François Lévesque1
    • Ju Weon Lee3
    • Andreas Seidel-Morgenstern3
    • Peter H. Seeberger1,2
    • 1Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany
    • 2Freie Universität Berlin, Germany
    • 3Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

    Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module (see scheme).

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