Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor

A continuous-flow approach to the hydrogenation of alkenes utilizing Wilkinson’s catalyst is reported. The approach relies on a newly developed coil design in which it is possible to load gas and heat the reaction mixture simultaneously. The hydrogenation of various substrates has been performed successfully on small scale and can be scaled up substantially.

• Michael A. Mercadante
• Christopher B. Kelly
• Christopher (Xiang) Lee
• Nicholas E. Leadbeater^*

• Department of Chemistry, University of Connecticut, USA

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