Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor

    Sean Newton1, Steven V. Ley1, Eva Casas Arcé2, Damian M. Grainger2

    • 1Department of Chemistry, University of Cambridge, U.K.
    • 2Johnson Matthey Catalysis and Chiral Technology, Cambridge, U.K.

    In this update, the asymmetric homogeneous hydrogenation of a number of trisubstituted olefins utilizing the recently developed tube-in-tube gas-liquid flow reactor is described. A number of chiral iridium- and rhodium-based catalysts and other parameters such as pressure, solvent, temperature and catalyst loading were screened. The advantage of the flow set-up for rapid screening and optimization of reaction parameters is illustrated. Furthermore, a comparative study using batch conditions aided in the optimization of the flow reaction set-up. The set-up was further modified to recycle the catalyst which prolonged catalytic activity.

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