An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

    • Marcus Baumann
    • Ian R. Baxendale
    • Malte Brasholz
    • John J. Hayward
    • Steven V. Ley
    • Nikzad Nikbin
    • Innovative Technology Centre, Cambridge, UK

    The bisoxazole containing natural product O-methyl siphonazole was assembled using a suite of microreactors via a flow-based approach in concert with traditional batch methods. The use of a toolbox of solid-supported scavengers and reagents to aid purification afforded the natural product in a total of nine steps.

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