An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

• Marcus Baumann
• Ian R. Baxendale
• Malte Brasholz
• John J. Hayward
• Steven V. Ley
• Nikzad Nikbin

• Innovative Technology Centre, Cambridge, UK

The bisoxazole containing natural product O-methyl siphonazole was assembled using a suite of microreactors via a flow-based approach in concert with traditional batch methods. The use of a toolbox of solid-supported scavengers and reagents to aid purification afforded the natural product in a total of nine steps.

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