An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

    Paolo Zambellia, Lucia Tamborinib, Samuele Cazzamallib, Andrea Pintob, Stefania Ariolia, Silvia Balzarettia, Francisco J. Plouc, Lucia Fernandez-Arrojoc, Francesco Molinaria, Paola Contib, Diego Romanoa

    • a Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli, 20133 Milan, Italy
    • b Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • c Instituto de Catálisis y Petroleoquímica, CSIC, 28049 Madrid, Spain

    A sustainable and scalable process for the production of a new mixture of fructooligosaccharides (FOS) was developed using a continuous-flow approach based on an immobilized whole cells-packed bed reactor. The technological transfer from a classical batch system to an innovative flow environment allowed a significant improvement of the productivity. Moreover, the stability of this production system was ascertained by up to 7 days of continuous working. These results suggest the suitability of the proposed method for a large-scale production of the desired FOS mixture, in view of a foreseeable use as a novel prebiotic preparation.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us