An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

    Paolo Zambellia, Lucia Tamborinib, Samuele Cazzamallib, Andrea Pintob, Stefania Ariolia, Silvia Balzarettia, Francisco J. Plouc, Lucia Fernandez-Arrojoc, Francesco Molinaria, Paola Contib, Diego Romanoa

    • a Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli, 20133 Milan, Italy
    • b Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • c Instituto de Catálisis y Petroleoquímica, CSIC, 28049 Madrid, Spain

    A sustainable and scalable process for the production of a new mixture of fructooligosaccharides (FOS) was developed using a continuous-flow approach based on an immobilized whole cells-packed bed reactor. The technological transfer from a classical batch system to an innovative flow environment allowed a significant improvement of the productivity. Moreover, the stability of this production system was ascertained by up to 7 days of continuous working. These results suggest the suitability of the proposed method for a large-scale production of the desired FOS mixture, in view of a foreseeable use as a novel prebiotic preparation.

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