Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Thomas M. Kohl ^*, Christian H. Hornung, John Tsanaktsidis

• CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.

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