A simple setup for transfer hydrogenations in flow chemistry

    Matthew Hutchings, Thomas Wirth*

    • School of Chemistry, Cardiff University, Cardiff CF10 3AT, UK

    By using a packed-bed reactor with a palladium charcoal catalyst and ammonium formate or triethylsilane as hydrogen/hydride source, various functional groups including nitro groups, azides and alkenes can be efficiently reduced by a transfer hydrogenation process under mild conditions in a simple flow system.

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