[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

    • Christopher D. Smith1
    • Ian R. Baxendale1
    • Steve Lanners1
    • John J. Hayward1
    • Steven V. Ley1
    • Stephen C. Smith2
    • 1Innovative Technology Centre, University of Cambridge, UK
    • 2Syngenta, Jealots Hill International Research Centre, UK

    The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

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