[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

• Christopher D. Smith¹
• Ian R. Baxendale¹
• Steve Lanners¹
• John J. Hayward¹
• Steven V. Ley¹
• Stephen C. Smith²

• ¹Innovative Technology Centre, University of Cambridge, UK
• ²Syngenta, Jealots Hill International Research Centre, UK

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

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