Publications

Peptides are essential bioactive compounds with broad applications in nutraceuticals, pharmaceuticals, cosmetics, and materials. As their applications continue to grow, the development of efficient and sustainable synthesis methods has emerged as a major focus of research. This r...

Screening identified 2-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylic acid (1) as a 55 µM dynaminGTPase inhibitor. Synthesis of three 1-based libraries shows no potency enhancement. However, S-isostere-based 3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxy...

Antimicrobial resistance is a growing threat to human health and agriculture. Sulfur-containing compounds and elemental sulfur have a long history of use as antimicrobials, but challenges related to solubility and formulation have limited their broad application. Recent advances ...

Flow reactors for Solid phase synthesis (SPS) have gained attention, as they appear to be more efficient than the widely used stirred tanks. In either Packed Bed (PBR) or Loose Bed Reactors (LBR) configurations, the theoretical description of such platforms is limited. This study...

This work presents a significantly improved and scaled continuous flow process for the synthesis of Propofol (2,6-diisopropylphenol), a WHO-essential anaesthetic agent. Building upon previous research, the two-step synthesis featuring a Friedel-Crafts bisalkylation of 4-hydroxybe...