Photochemical flow synthesis of 3‐hydroxyazetidines

    Michele Ruggeri1, Amanda Worthy Dombrowski2, Stevan W. Djuric2, Ian Richard Baxendale1

    • 1University of Durham, Department of Chemistry, South Road, DH1 3LE Durham, UNITED KINGDOM
    • 2AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064 Chicago, UNITED STATES

    A photo‐flow Norrish‐Yang cyclisation has been devised that delivers 3‐hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuable chemical entities at synthetically useful multi‐gram scales. A systematic exploration of the constituent structural components was undertaken allowing an understanding of the reactivity and functional group tolerance of the transformation.

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