Novel Applications of α-Diazocarbonyl Compounds and Enabling Technologies in Stereoselective Synthesis

Micol Santi

• PhD Thesis, May 2020, Cardiff University

α-Diazocarbonyl compounds are widely used in organic chemistry as versatile carbene precursors which enable concise synthesis towards complex asymmetric molecules. Due to their intrinsic highly energetic nature, flow technology can be applied to ensure safer, scalable and efficient protocols. Other modern enabling tools such as Design of Experiment (DoE) and online analysis, provide great advantages to achieve faster analysis and optimisations of chemical transformations.

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