Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines

• Qinghuan Wu^a, Luchao Li^a, Binyan Xu^a, Jie Sun^a, Dong Ji^b, Yuguang Li^b, Lei Shen^b, Zheng Fang^a, Jindian Duan^a, Beining Chen^c, Kai Guo^a

• ^aCollege of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China
• ^bInstitute of Nanjing Advanced Biomaterials & Processing Equipment, Nanjing, 211299, China
• ^cDepartment of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK

An iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates is described. This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted pyrimidines under batch and continuous flow conditions in moderate to good yields, exhibiting good functional group tolerance, scalability and operational simplicity.

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