Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor

    • Wouter Debrouwer,a*
    • Wim Kimpea
    • Ruben Dangreau,a
    • Kevin Huvaere,a
    • Hannes P.L. Gemoets,b
    • Milad Mottaghi,c
    • Simon Kuhn,c
    • Koen Van Akenab
    • aEcoSynth, Industrielaan 12, 9800 Deinze, Belgium
    • bCreaflow, Industrielaan 12, 9800 Deinze, Belgium
    • c Department of Chemical Engineering, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium

    Continuous flow reactor technology has a proven track record in enabling photochemical transformations. However, transfer of a photochemical batch process to a flow protocol often remains elusive, especially when solid reagents or catalysts are employed. In this work, application of an oscillatory plug flow photoreactor enabled a heterogeneous MacMillan-type C(sp²) – C(sp³) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over mixing intensity and residence time distribution (RTD), pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp²) – C(sp³) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity (0.87 g/h).

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us

    Request a quote