Integrated plug flow synthesis and crystallisation of pyrazinamide

• C. Daniel Scott^a
• Ricardo Labes^b
• Martin Depardieu^c
• Claudio Battilocchio^b
• Matthew G. Davidson^a
• Steven V. Ley^b
• Chick C. Wilson^ad
• and Karen Robertson^*c

• ^a Centre for Sustainable Chemical Technologies, Department of Chemistry, University of Bath, UK
• ^b Department of Chemistry, University of Cambridge, UK
• ^c Department of Chemistry, University of Bath, UK
• ^d EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, University of Bath, UK

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

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