Integrated plug flow synthesis and crystallisation of pyrazinamide

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

• C. Daniel Scott^a
• Ricardo Labes^b
• Martin Depardieu^c
• Claudio Battilocchio^b
• Matthew G. Davidson^a
• Steven V. Ley^b
• Chick C. Wilson^ad
• and Karen Robertson^*c

• ^a Centre for Sustainable Chemical Technologies, Department of Chemistry, University of Bath, UK
• ^b Department of Chemistry, University of Cambridge, UK
• ^c Department of Chemistry, University of Bath, UK
• ^d EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, University of Bath, UK

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