Grignard reagents on a tab: direct magnesium insertion under flow conditions

• Lena Huck^†,‡
• Antonio de la Hoz^‡
• Angel Díaz-Ortiz^‡
• Jesus Alcázar^†

• ^† Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain
• ^‡ Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain

An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch reactions allow access to a diverse set of functional groups.

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