Flow Electrochemical Cyclizations via Amidyl Radicals: Easy Access to Cyclic Ureas

    Nisar Ahmeda,b*, Aggeliki Vgenopouloua

    • a School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK
    • b School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK

    Flow chemistry has advantages over batch processes and can achieve the synthesis of substances in high yield under safe working conditions. The combination of electrochemistry and flow microreactor technology has made chemical transformations possible without the use of oxidants or catalysts. Herein, we report flow electrosynthesis of cyclic ureas via oxyamination of N-allylic ureas. We have found that continuous flow is able to outperform its batch counterpart, producing cyclic ureas in excellent yields.

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