Flow Chemistry Opportunities for Drug Discovery

• María Lourdes Linares^a
• Enol López^b
• Eduardo Palao^a
• Jesús Alcázar^a

• ^aJanssen Research and Development, Janssen-Cilag, S.A., Discovery Chemistry, C/ Jarama, 75, 45007 Toledo Spain
• ^bUniversidad de Castilla-La Mancha, Facultad de Ciencias y Tecnologías Químicas, Av. Camilo José Cela, 14, 13005 Ciudad Real Spain

This chapter provides an overview on how flow chemistry can be integrated in the drug discovery process, going beyond traditional transformations applied in the Pharma sector and accessing novel chemical space. Its combination with photochemistry and electrochemistry is allowing the development of new reactivities to access complex molecules in a more efficient way. Integration of flow chemistry in automated platforms will enhance its productivity and reduce cycle times in drug discovery.

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